In 2005 and 2006 she was nominated for a Golden Globe Award in the Best Actress category. She was also nominated for an Emmy in the Best Actress in a Comedy Series category in 2005.
Prior to her role on Desperate Housewives, she starred as Dr. Linda Abbott on The WB's critically-acclaimed series, Everwood. She is also well known for her role as Dr. Kimberly Shaw on the hit drama Melrose Place.
On stage, Cross performed in The Merchant of Venice at the Folger Theatre, La Ronde at the Williamstown Theater Festival, Twelfth Night at the Hartford Stage Company, and in The Two Gentlemen of Verona at the Old Globe Theatre.
Aside from her successful career as an actress, Cross has also made time to continue her education, earning a master's degree in psychology.